development and controversy of competitive endogenous RNA hypothesis in non-coding genes

development and controversy of competitive endogenous RNA hypothesis in non-coding genes

RNA silencing of hormonal biosynthetic genes impairs larval progress and improvement in cotton bollworm, Helicoverpa armigera

The cotton bollworm, Helicoverpa armigera, is a extremely polyphagous pest, inflicting monumental losses to numerous economically vital crops. The identification and in vitro useful validation of goal genes of a pest is a prerequisite to fight pest through host-mediated RNA interference (RNAi).

Within the current examine, six hormonal biosynthesis genes of H. armigera had been chosen and evaluated by feeding insect larvae with dsRNAs corresponding to every goal gene, viz., juvenile hormone acid methyltransferase (HaJHAMT), prothoracicotropic hormone (HaPTTH), pheromone biosynthesis-activating peptide (HaPBAP), molt regulating transcription issue (HaHR3), activated protein 4 (HaAP-4) and eclosion hormone precursor (HaEHP).

The lack of perform phenotypes for these hormonal genes had been noticed by releasing second instar larvae on to synthetic weight loss program containing goal gene-specific dsRNAs. Ingestion of dsRNAs resulted in mortality starting from 60% to 90%, decreased larval weight, phenotypic deformities and delayed pupation. The quantitative real-time PCR (qRT-PCR) evaluation confirmed that the goal gene transcript ranges had been decreased drastically (31% to 77%) as in comparison with management or unrelated management (GFP-dsRNA), and correlated nicely with the mortality and developmental defects of larvae.

Additionally, a comparability of the silencing efficacy of un-diced lengthy HaPTTH -dsRNAwith RNase III diced HaPTTH-dsRNA (siRNAs) revealed that lengthy dsRNAs had been extra environment friendly in silencing the goal gene. These outcomes indicated that the hormonal biosynthesis genes have different sensitivity in direction of RNAi and could possibly be the very important targets for insect resistance in crop vegetation like cotton that are infested by H. armigera.

The event and controversy of aggressive endogenous RNA speculation in non-coding genes

As a momentous post-transcriptional regulator, microRNAs (miRNAs) are attracting an increasing number of consideration. The classical miRNAs regulated mechanism reveals it binds to the targets’ 3’UTR thus play the position in post-transcription.

In the meantime, single miRNA can goal a number of genes, so these ought to compete to bind that miRNA. Vice versa, single gene can sponge mass of miRNAs as nicely. Thus the aggressive endogenous RNAs (ceRNAs) speculation was put ahead in 2011.

The ceRNA speculation has made large achievements, specifically in non-coding genes, which together with lengthy non-coding RNAs (lncRNAs), circle RNAs (circRNAs) and pseudogenes, even viral transcripts. It additionally contributed enormously to epigenetics improvement.

Nonetheless, an growing variety of controversies have occurred with applause. Primarily based on this case, this evaluate introduces one thing intimately concerning the ceRNAs speculation achieved in lncRNAs,circRNAs, pseudogenes and viral transcripts, respectively. In the meantime, it additionally covers controversy of the ceRNAs speculation

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Transcription Factor P65 (NFKB3) Antibody
abx037885-100ug 100 ug
EUR 391
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Transcription Factor P65 (NFKB3) Antibody
abx038310-100ug 100 ug
EUR 391
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Polyclonal Goat anti-GST α-form
GST-ANTI-1 50 uL
EUR 280
Polyclonal Goat anti-GST μ-form
GST-ANTI-2 50 uL
EUR 280
Polyclonal Goat anti-GST p-form
GST-ANTI-3 50 uL
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Human Transcription factor p65 protein (NFKB3)
1-CSB-RP039844h
  • EUR 380.00
  • EUR 214.00
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  • EUR 560.00
  • EUR 873.00
  • EUR 262.00
  • 100ug
  • 10ug
  • 1MG
  • 200ug
  • 500ug
  • 50ug
  • MW: 50.6 kDa
  • Buffer composition: Tris-based buffer with 50% glycerol.
Description: Recombinant Human Transcription factor p65 protein(NFKB3),partial expressed in E.coli
Human Transcription factor p65 protein (NFKB3)
1-CSB-RP039874h
  • EUR 380.00
  • EUR 214.00
  • EUR 1309.00
  • EUR 560.00
  • EUR 873.00
  • EUR 262.00
  • 100ug
  • 10ug
  • 1MG
  • 200ug
  • 500ug
  • 50ug
  • MW: 27.6 kDa
  • Buffer composition: Tris-based buffer with 50% glycerol.
Description: Recombinant Human Transcription factor p65 protein(NFKB3),partial expressed in E.coli
Rat Transcription factor p65 / NFKB3 (RELA) ELISA Kit
20-abx156040
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  • EUR 895.00
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Human Transcription factor p65 / NFKB3 (RELA) ELISA Kit
20-abx152945
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  • EUR 825.00
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Mouse Transcription factor p65 / NFKB3 (RELA) ELISA Kit
abx254289-96tests 96 tests
EUR 668
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Rat Transcription factor p65 / NFKB3 (RELA) ELISA Kit
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EUR 668
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Human Transcription factor p65 / NFKB3 (RELA) ELISA Kit
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EUR 668
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EUR 825
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EUR 825
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Sheep Transcription factor p65 / NFKB3 (RELA) ELISA Kit
abx364265-96tests 96 tests
EUR 926
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Human Transcription factor p65 / NFKB3 (RELA) ELISA Kit
abx570125-96tests 96 tests
EUR 668
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Mouse Transcription factor p65 / NFKB3 (RELA) ELISA Kit
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EUR 668
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Guinea pig Transcription factor p65 / NFKB3 (RELA) ELISA Kit
abx357262-96tests 96 tests
EUR 825
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Anti-Anti-SEPT6 antibody antibody
STJ11100949 100 µl
EUR 277
Description: This gene is a member of the septin family of GTPases. Members of this family are required for cytokinesis. One version of pediatric acute myeloid leukemia is the result of a reciprocal translocation between chromosomes 11 and X, with the breakpoint associated with the genes encoding the mixed-lineage leukemia and septin 2 proteins. This gene encodes four transcript variants encoding three distinct isoforms. An additional transcript variant has been identified, but its biological validity has not been determined.
Anti-Anti-SEPT9 Antibody antibody
STJ111369 100 µl
EUR 277
Description: This gene is a member of the septin family involved in cytokinesis and cell cycle control. This gene is a candidate for the ovarian tumor suppressor gene. Mutations in this gene cause hereditary neuralgic amyotrophy, also known as neuritis with brachial predilection. A chromosomal translocation involving this gene on chromosome 17 and the MLL gene on chromosome 11 results in acute myelomonocytic leukemia. Multiple alternatively spliced transcript variants encoding different isoforms have been described.
Anti-Anti-SEPT11 Antibody antibody
STJ111530 100 µl
EUR 277
Anti-Anti-SEPT4 Antibody antibody
STJ112276 100 µl
EUR 277
Description: This gene is a member of the septin family of nucleotide binding proteins, originally described in yeast as cell division cycle regulatory proteins. Septins are highly conserved in yeast, Drosophila, and mouse, and appear to regulate cytoskeletal organization. Disruption of septin function disturbs cytokinesis and results in large multinucleate or polyploid cells. This gene is highly expressed in brain and heart. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. One of the isoforms (known as ARTS) is distinct; it is localized to the mitochondria, and has a role in apoptosis and cancer.
Anti-Anti-SEPT2 Antibody antibody
STJ25475 100 µl
EUR 277
Anti-Anti-SEPT5 Antibody antibody
STJ25477 100 µl
EUR 277
Description: This gene is a member of the septin gene family of nucleotide binding proteins, originally described in yeast as cell division cycle regulatory proteins. Septins are highly conserved in yeast, Drosophila, and mouse and appear to regulate cytoskeletal organization. Disruption of septin function disturbs cytokinesis and results in large multinucleate or polyploid cells. This gene is mapped to 22q11, the region frequently deleted in DiGeorge and velocardiofacial syndromes. A translocation involving the MLL gene and this gene has also been reported in patients with acute myeloid leukemia. Alternative splicing results in multiple transcript variants. The presence of a non-consensus polyA signal (AACAAT) in this gene also results in read-through transcription into the downstream neighboring gene (GP1BB; platelet glycoprotein Ib), whereby larger, non-coding transcripts are produced.
Anti-Anti-SEPT8 Antibody antibody
STJ25479 100 µl
EUR 277
Description: This gene is a member of the septin family of nucleotide binding proteins, originally described in yeast as cell division cycle regulatory proteins. Septins are highly conserved in yeast, Drosophila, and mouse, and appear to regulate cytoskeletal organization. Disruption of septin function disturbs cytokinesis and results in large multinucleate or polyploid cells. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene.
Anti-Anti-SEPT2 Antibody antibody
STJ28365 100 µl
EUR 277
Anti-Anti-SEPT7 Antibody antibody
STJ28963 100 µl
EUR 277
Description: This gene encodes a protein that is highly similar to the CDC10 protein of Saccharomyces cerevisiae. The protein also shares similarity with Diff 6 of Drosophila and with H5 of mouse. Each of these similar proteins, including the yeast CDC10, contains a GTP-binding motif. The yeast CDC10 protein is a structural component of the 10 nm filament which lies inside the cytoplasmic membrane and is essential for cytokinesis. This human protein functions in gliomagenesis and in the suppression of glioma cell growth, and it is required for the association of centromere-associated protein E with the kinetochore. Alternative splicing results in multiple transcript variants. Several related pseudogenes have been identified on chromosomes 5, 7, 9, 10, 11, 14, 17 and 19.
Anti-Anti-MARCH9 Antibody antibody
STJ112609 100 µl
EUR 277
Anti-Anti-SEPT11 Antibody antibody
STJ113941 100 µl
EUR 277
Anti-Anti-SEPT11 Antibody antibody
STJ114081 100 µl
EUR 277
Anti-Anti-SEPT5 Antibody antibody
STJ114819 100 µl
EUR 277
Description: This gene is a member of the septin gene family of nucleotide binding proteins, originally described in yeast as cell division cycle regulatory proteins. Septins are highly conserved in yeast, Drosophila, and mouse and appear to regulate cytoskeletal organization. Disruption of septin function disturbs cytokinesis and results in large multinucleate or polyploid cells. This gene is mapped to 22q11, the region frequently deleted in DiGeorge and velocardiofacial syndromes. A translocation involving the MLL gene and this gene has also been reported in patients with acute myeloid leukemia. Alternative splicing results in multiple transcript variants. The presence of a non-consensus polyA signal (AACAAT) in this gene also results in read-through transcription into the downstream neighboring gene (GP1BB; platelet glycoprotein Ib), whereby larger, non-coding transcripts are produced.
Anti-Anti-MARCH8 Antibody antibody
STJ114828 100 µl
EUR 277
Anti-Anti-SEPT7 Antibody antibody
STJ116214 100 µl
EUR 277
Description: This gene encodes a protein that is highly similar to the CDC10 protein of Saccharomyces cerevisiae. The protein also shares similarity with Diff 6 of Drosophila and with H5 of mouse. Each of these similar proteins, including the yeast CDC10, contains a GTP-binding motif. The yeast CDC10 protein is a structural component of the 10 nm filament which lies inside the cytoplasmic membrane and is essential for cytokinesis. This human protein functions in gliomagenesis and in the suppression of glioma cell growth, and it is required for the association of centromere-associated protein E with the kinetochore. Alternative splicing results in multiple transcript variants. Several related pseudogenes have been identified on chromosomes 5, 7, 9, 10, 11, 14, 17 and 19.
Anti-Anti-SEPT8 Antibody antibody
STJ117206 100 µl
EUR 277
Description: This gene is a member of the septin family of nucleotide binding proteins, originally described in yeast as cell division cycle regulatory proteins. Septins are highly conserved in yeast, Drosophila, and mouse, and appear to regulate cytoskeletal organization. Disruption of septin function disturbs cytokinesis and results in large multinucleate or polyploid cells. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene.
Anti-Anti-SEPT12 Antibody antibody
STJ117759 100 µl
EUR 277
Description: This gene encodes a guanine-nucleotide binding protein and member of the septin family of cytoskeletal GTPases. Septins play important roles in cytokinesis, exocytosis, embryonic development, and membrane dynamics. Multiple transcript variants encoding different isoforms have been found for this gene.
Anti-Anti-MARCH6 Antibody antibody
STJ118549 100 µl
EUR 277
Anti-Anti-MARCH6 Antibody antibody
STJ118550 100 µl
EUR 277
Anti-Anti-MARCH7 Antibody antibody
STJ118752 100 µl
EUR 277
Anti-Anti-SEPT3 Antibody antibody
STJ118990 100 µl
EUR 277
Anti-Anti-SEPT1 antibody antibody
STJ119580 100 µl
EUR 277
Description: This gene is a member of the septin family of GTPases. Members of this family are required for cytokinesis and the maintenance of cellular morphology. This gene encodes a protein that can form homo- and heterooligomeric filaments, and may contribute to the formation of neurofibrillary tangles in Alzheimer's disease. Alternatively spliced transcript variants have been found but the full-length nature of these variants has not been determined. [provided by RefSeq, Dec 2012]
Anti-Anti-DDB1 Antibody
A00333 100uL
EUR 455
Description: Rabbit Polyclonal DDB1 Antibody. Validated in IP and tested in Human, Mouse.
Human Anti-Anti-Sperm Antibody Antibody (Anti-AsAb) ELISA Kit
AEA465Hu-10x96wellstestplate 10x96-wells test plate
EUR 5647.8
  • The Intra-assay Precision is determined when 3 samples with low, middle and high level of Human Anti-Anti-Sperm Antibody Antibody (Anti-AsAb) were tested on 3 different plates, 8 replicates in each plate
  • CV(%) = SD/meanX100
  • Intra-Assay: CV<10%
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Description: This is Competitive Enzyme-linked immunosorbent assay for Antibody Detection.detection of Human Anti-Anti-Sperm Antibody Antibody (Anti-AsAb) in serum, plasma and other biological fluids.
Human Anti-Anti-Sperm Antibody Antibody (Anti-AsAb) ELISA Kit
AEA465Hu-1x48wellstestplate 1x48-wells test plate
EUR 552.76
  • The Intra-assay Precision is determined when 3 samples with low, middle and high level of Human Anti-Anti-Sperm Antibody Antibody (Anti-AsAb) were tested on 3 different plates, 8 replicates in each plate
  • CV(%) = SD/meanX100
  • Intra-Assay: CV<10%
  • Int
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Description: This is Competitive Enzyme-linked immunosorbent assay for Antibody Detection.detection of Human Anti-Anti-Sperm Antibody Antibody (Anti-AsAb) in serum, plasma and other biological fluids.
Human Anti-Anti-Sperm Antibody Antibody (Anti-AsAb) ELISA Kit
AEA465Hu-1x96wellstestplate 1x96-wells test plate
EUR 746.8
  • The Intra-assay Precision is determined when 3 samples with low, middle and high level of Human Anti-Anti-Sperm Antibody Antibody (Anti-AsAb) were tested on 3 different plates, 8 replicates in each plate
  • CV(%) = SD/meanX100
  • Intra-Assay: CV<10%
  • Int
  • Show more
Description: This is Competitive Enzyme-linked immunosorbent assay for Antibody Detection.detection of Human Anti-Anti-Sperm Antibody Antibody (Anti-AsAb) in serum, plasma and other biological fluids.
Human Anti-Anti-Sperm Antibody Antibody (Anti-AsAb) ELISA Kit
AEA465Hu-5x96wellstestplate 5x96-wells test plate
EUR 3060.6
  • The Intra-assay Precision is determined when 3 samples with low, middle and high level of Human Anti-Anti-Sperm Antibody Antibody (Anti-AsAb) were tested on 3 different plates, 8 replicates in each plate
  • CV(%) = SD/meanX100
  • Intra-Assay: CV<10%
  • Int
  • Show more
Description: This is Competitive Enzyme-linked immunosorbent assay for Antibody Detection.detection of Human Anti-Anti-Sperm Antibody Antibody (Anti-AsAb) in serum, plasma and other biological fluids.
Human Anti-Anti-Sperm Antibody Antibody (Anti-AsAb) ELISA Kit
4-AEA465Hu
  • EUR 5698.00
  • EUR 3011.00
  • EUR 747.00
  • 10 plates of 96 wells
  • 5 plates of 96 wells
  • 1 plate of 96 wells
  • Known also as Anti-Sperm Antibody elisa. Alternative names of the recognized antigen: Anti-Spermatozoa Antibodies
  • Sperm Antibodies
  • Antisperm Antibodies
Description: Enzyme-linked immunosorbent assay based on the Competitive Inhibition method for detection of Human Anti-Anti-Sperm Antibody Antibody (Anti-AsAb) in samples from serum, plasma and other biological fluids with no significant corss-reactivity with analogues from other species.
ELISA kit for Human Anti-AsAb (Anti-Anti-Sperm Antibody Antibody)
ELK8071 1 plate of 96 wells
EUR 432
  • The microtiter plate provided in this kit has been pre-coated with an antigen. Standards or samples are then added to the appropriate microtiter plate wells with a Horseradish Peroxidase (HRP)-conjugated secondary antibody. After TMB substrate soluti
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Description: A competitive Inhibition ELISA kit for detection of Anti-Anti-Sperm Antibody Antibody from Human in samples from blood, serum, plasma, cell culture fluid and other biological fluids.
Anti-CYFIP2 Antibody
A06562 100ul
EUR 397
Description: Rabbit Polyclonal Antibody for CYFIP2 Antibody (CYFIP2) detection.tested for IHC, WB in Human, Mouse, Rat.
Anti-GPS2 Antibody
A06569 100ul
EUR 397
Description: Rabbit Polyclonal Antibody for GPS2 Antibody (GPS2) detection. Tested with WB in Human, Mouse, Rat.
Anti-PRKX Antibody
A06585-1 100ul
EUR 397
Description: Rabbit Polyclonal PRKX Antibody. Validated in IHC, WB and tested in Human, Mouse, Rat.
Anti-PPA2 Antibody
A06587 100ug/vial
EUR 294
Anti-GluR8 Antibody
A06589 100ul
EUR 397
Description: Rabbit Polyclonal GluR8 Antibody. Validated in IHC, WB and tested in Human, Mouse, Rat.
Anti-EDG7 Antibody
A06597-1 100ul
EUR 397
Description: Rabbit Polyclonal EDG7 Antibody. Validated in IF, WB and tested in Human, Mouse, Rat.
Anti-KIR2.3 Antibody
A06605-1 100ul
EUR 397
Description: Rabbit Polyclonal Antibody for KIR2.3 Antibody (KCNJ4) detection. Tested with WB in Human, Mouse, Rat.
Anti-GALK1 Antibody
A06627 100ul
EUR 397
Description: Rabbit Polyclonal GALK1 Antibody. Validated in WB and tested in Human, Mouse, Rat.
Anti-PRAME Antibody
A06628-2 100ug/vial
EUR 294
Anti-GP2 Antibody
A06630-1 100ug/vial
EUR 334
Anti-USP21 Antibody
A06639 100ug/200ul
EUR 397
Description: Goat Polyclonal USP21 Antibody. Validated in WB and tested in Human, Mouse, Rat.
Anti-TLK2 Antibody
A06645 100ul
EUR 397
Description: Rabbit Polyclonal Antibody for TLK2 Antibody (TLK2) detection. Tested with WB in Human, Mouse.
Anti-PPP1R3C Antibody
A06658 100ul
EUR 397
Description: Rabbit Polyclonal PPP1R3C Antibody. Validated in WB and tested in Human.
Anti-LRRK1 Antibody
A06670 100ul
EUR 397
Description: Rabbit Polyclonal LRRK1 Antibody. Validated in IF, IHC and tested in Human.
Anti-MNDA Antibody
A06675 100ul
EUR 397
Description: Rabbit Polyclonal MNDA Antibody. Validated in WB and tested in Human.
Anti-KAL1 Antibody
A06684 100ul
EUR 397
Description: Rabbit Polyclonal KAL1 Antibody. Validated in WB and tested in Human.
Anti-COL14A1 Antibody
A06685 100ul
EUR 397
Description: Rabbit Polyclonal Antibody for COL14A1 Antibody (COL14A1) detection.tested for IHC in Human, Mouse, Rat.
Anti-CYP4B1 Antibody
A06690 100ul
EUR 397
Description: Rabbit Polyclonal Antibody for CYP4B1 Antibody (CYP4B1) detection.tested for WB in Human.
Anti-RFX2 Antibody
A06709 100ul
EUR 397
Description: Rabbit Polyclonal RFX2 Antibody. Validated in IHC and tested in Human.
Anti-GPR92 Antibody
A06721 100ul
EUR 397
Description: Rabbit Polyclonal Antibody for GPR92 Antibody (LPAR5) detection. Tested for WB, IHC, IF in Human.
Anti-MBTPS1 Antibody
A06735 100ul
EUR 397
Description: Rabbit Polyclonal MBTPS1 Antibody. Validated in WB and tested in Human, Mouse, Rat.
Anti-PLA2G1B Antibody
A06738 100ug/200ul
EUR 397
Description: Goat Polyclonal PLA2G1B Antibody. Validated in WB and tested in Human.
Anti-GNB5 Antibody
A06754 100ul
EUR 397
Description: Rabbit Polyclonal GNB5 Antibody. Validated in IHC, WB and tested in Human.
Anti-BAIAP2L1 Antibody
A06770 100ul
EUR 397
Description: Rabbit Polyclonal BAIAP2L1 Antibody. Validated in WB and tested in Human.
Anti-IRTKS Antibody
A06770-1 100ul
EUR 397
Description: Rabbit Polyclonal Antibody for IRTKS Antibody (BAIAP2L1) detection.tested for WB in Human, Mouse, Rat.
Anti-MLF1 Antibody
A06772 100ul
EUR 397
Description: Rabbit Polyclonal MLF1 Antibody. Validated in WB and tested in Human, Mouse.
Anti-NDR2 Antibody
A06774 100ul
EUR 397
Description: Rabbit Polyclonal Antibody for NDR2 Antibody (STK38L) detection.tested for WB in Human, Mouse, Rat.
Anti-LARG Antibody
A06802-1 100ul
EUR 397
Description: Rabbit Polyclonal Antibody for LARG Antibody (ARHGEF12) detection. Tested with WB in Human, Mouse, Rat.
Anti-GAS1 Antibody
A06815-1 100ul
EUR 397
Description: Rabbit Polyclonal GAS1 Antibody. Validated in WB and tested in Human, Mouse.
Anti-APLF Antibody
A06828-1 100ul
EUR 397
Description: Rabbit Polyclonal Antibody for APLF Antibody (APLF) detection.tested for WB in Human, Mouse.
Anti-PKCB1 Antibody
A06830 100ul
EUR 397
Description: Rabbit Polyclonal PKCB1 Antibody. Validated in WB and tested in Human.
Anti-DnaJB4 Antibody
A06835-1 100ul
EUR 397
Description: Rabbit Polyclonal Antibody for DnaJB4 Antibody (DNAJB4) detection.tested for WB in Human, Mouse, Rat.
Anti-ArfGAP3 Antibody
A06839 100uL
EUR 455
Description: Rabbit Polyclonal ArfGAP3 Antibody. Validated in IP, IF, WB and tested in Human.
Anti-SCN2B Antibody
A06842 100ul
EUR 397
Description: Rabbit Polyclonal SCN2B Antibody. Validated in WB and tested in Human.
Anti-CD316 Antibody
A06844 100ul
EUR 397
Description: Rabbit Polyclonal Antibody for CD316 Antibody (IGSF8) detection. Tested with WB in Human, Mouse.
Anti-AMOTL2 Antibody
A06852 100ug/vial
EUR 294
Anti-POM121 Antibody
A06856 100ul
EUR 397
Description: Rabbit Polyclonal POM121 Antibody. Validated in WB and tested in Human, Mouse, Rat.
Anti-TBX22 Antibody
A06861 100ul
EUR 397
Description: Rabbit Polyclonal TBX22 Antibody. Validated in WB and tested in Human.
Anti-QORX Antibody
A06870 100ul
EUR 397
Description: Rabbit Polyclonal QORX Antibody. Validated in WB and tested in Human.
Anti-ADAM28 Antibody
A06873-1 100ug/vial
EUR 294
Anti-Adam28 Antibody
A06873-2 100ug/vial
EUR 334
Anti-KSR2 Antibody
A06876 100ul
EUR 397
Description: Rabbit Polyclonal KSR2 Antibody. Validated in IF, WB and tested in Human, Mouse.
Anti-Recoverin Antibody
A06882 100ul
EUR 397
Description: Rabbit Polyclonal Antibody for Recoverin Antibody (RCVRN) detection.tested for WB in Human, Mouse.
Anti-CRP1 Antibody
A06894 100ul
EUR 397
Description: Rabbit Polyclonal CRP1 Antibody. Validated in IHC, WB and tested in Human, Mouse, Rat.
Anti-CD297 Antibody
A06913 100ul
EUR 397
Description: Rabbit Polyclonal Antibody for CD297 Antibody (ART4) detection.tested for IHC in Human.
Anti-TAF12 Antibody
A06944-1 100ug/vial
EUR 334
Anti-AKR7A2 Antibody
A06949-1 100ug/vial
EUR 334
Anti-IPMK Antibody
A06955 100ul
EUR 397
Description: Rabbit Polyclonal IPMK Antibody. Validated in WB and tested in Human, Mouse, Rat.
Anti-ARHGEF10 Antibody
A06958 100ul
EUR 397
Description: Rabbit Polyclonal Antibody for ARHGEF10 Antibody (ARHGEF10) detection.tested for WB in Human, Monkey.

Conserved Patterns in Developmental Processes and Phases, Moderately than Genes, Unite the Extremely Divergent Bilateria

Bilateria are the predominant clade of animals on Earth. Regardless of having developed all kinds of physique plans and developmental modes, they’re characterised by frequent morphological traits. By default, researchers have tried to hyperlink clade-specific genes to those traits, thus distinguishing bilaterians from non-bilaterians, by their gene content material.

Right here we argue that it’s reasonably organic processes that unite Bilateria and set them aside from their non-bilaterian sisters, with a much less advanced physique morphology. To check this speculation, we in contrast proteomes of bilaterian and non-bilaterian species in an elaborate computational pipeline, aiming to seek for a set of bilaterian-specific genes.

Regardless of the restricted confidence of their bilaterian specificity, we nonetheless detected Bilateria-specific useful and developmental patterns within the sub-set of genes conserved in distantly associated Bilateria. Utilizing a novel multi-species GO-enrichment methodology, we decided the useful repertoire of genes which can be broadly conserved amongst Bilateria. Analyzing expression profiles in three very distantly associated mannequin species-D. melanogasterD. rerio and C. elegans-we discover attribute peaks at comparable phases of improvement and a delayed onset of expression in embryos. Specifically, the expression of the conserved genes seems to peak on the phylotypic stage of various bilaterian phyla.

In abstract, our examine illustrate how improvement connects distantly associated Bilateria after thousands and thousands of years of divergence, pointing to processes doubtlessly separating them from non-bilaterians. We argue that evolutionary biologists ought to return from a purely gene-centric view of evolution and place extra concentrate on analyzing and defining conserved developmental processes and durations.

Characterizing patient-oncologist communication in genomic tumor testing: The 21-gene recurrence rating as an exemplar

Goal: Ladies with early-stage, ER + breast most cancers are advocate to obtain genomic profiling assessments, corresponding to the 21-gene Recurrence Rating (RS) check, to information therapy choices. We examined test- and treatment-related data mentioned and the associations between RS classes and facets of communication throughout patient-oncologist medical encounters.

Strategies: As half of a bigger trial, medical encounters (N = 46) had been audiorecorded and coded for 1) RS- and treatment-related data, 2) shared determination making, 3) affected person lively participation, and 4) oncologist patient-centered communication. We examined variations by RS class utilizing blended fashions, adjusting for nesting inside oncologist.

Outcomes: Sufferers with a excessive RS had been extra more likely to obtain a chemotherapy advice (p < .01), hear concerning the dangers/uncomfortable side effects of chemotherapy (p < .01), and supply their preferences (p = .02) than these with intermediate or low RS. Parts of shared determination making elevated with RS. Oncologist patient-centered communication (M = 4.09/5, SD = .25) and affected person lively participation (M = 3.5/4, SD = 1.0) had been excessive throughout RS.

Conclusion: Findings counsel that illness severity, reasonably than medical uncertainty, affect therapy suggestions and shared determination making.

Apply implications: Oncologists alter test- and treatment-related data and shared determination making by illness severity. This data offers a framework to tell determination making in advanced most cancers and genomics settings.

CRISPR-Cas, a strong gene-editing know-how within the period of recent most cancers immunotherapy

Most cancers immunotherapy has been emerged as a promising technique for therapy of a broad spectrum of malignancies starting from hematological to stable tumors. One of many principal approaches of most cancers immunotherapy is switch of pure or engineered tumor-specific T-cells into sufferers,

a so known as “adoptive cell switch”, or ACT, course of. Development of allogeneic T-cells relies on the employment of a gene-editing device to switch donor-extracted T-cells and put together them to particularly act in opposition to tumor cells with enhanced perform and sturdiness and least side-effects. On this context, CRISPR know-how can be utilized to provide common T-cells, outfitted with recombinant T cell receptor (TCR) or chimeric antigen receptor (CAR), by means of multiplex genome engineering utilizing Cas nucleases.

The sturdy potential of CRISPR-Cas in getting ready the constructing blocks of ACT immunotherapy has broaden the appliance of such therapies and a few of them have gotten FDA approvals. Right here, we’ve collected the final investigations within the area of immuno-oncology performed in partnership with CRISPR know-how. As well as, research which have addressed the challenges within the path of CRISPR-mediated most cancers immunotherapy, in addition to pre-treatment purposes of CRISPR-Cas have been talked about intimately.

 

Mouse V-Myc Myelocytomatosis Viral Oncogene Homolog (MYC) ELISA Kit

DLR-MYC-Mu-96T 96T
EUR 661
  • Should the Mouse V-Myc Myelocytomatosis Viral Oncogene Homolog (MYC) ELISA Kit is proven to show malperformance, you will receive a refund or a free replacement.
Description: A sandwich quantitative ELISA assay kit for detection of Mouse V-Myc Myelocytomatosis Viral Oncogene Homolog (MYC) in samples from tissue homogenates, cell lysates or other biological fluids.

Rat V-Myc Myelocytomatosis Viral Oncogene Homolog (MYC) ELISA Kit

DLR-MYC-Ra-48T 48T
EUR 528
  • Should the Rat V-Myc Myelocytomatosis Viral Oncogene Homolog (MYC) ELISA Kit is proven to show malperformance, you will receive a refund or a free replacement.
Description: A sandwich quantitative ELISA assay kit for detection of Rat V-Myc Myelocytomatosis Viral Oncogene Homolog (MYC) in samples from serum, plasma, tissue homogenates, cell lysates or other biological fluids.

Rat V-Myc Myelocytomatosis Viral Oncogene Homolog (MYC) ELISA Kit

DLR-MYC-Ra-96T 96T
EUR 690
  • Should the Rat V-Myc Myelocytomatosis Viral Oncogene Homolog (MYC) ELISA Kit is proven to show malperformance, you will receive a refund or a free replacement.
Description: A sandwich quantitative ELISA assay kit for detection of Rat V-Myc Myelocytomatosis Viral Oncogene Homolog (MYC) in samples from serum, plasma, tissue homogenates, cell lysates or other biological fluids.

Human V-Myc Myelocytomatosis Viral Oncogene Homolog (MYC) ELISA Kit

RDR-MYC-Hu-48Tests 48 Tests
EUR 522

Human V-Myc Myelocytomatosis Viral Oncogene Homolog (MYC) ELISA Kit

RDR-MYC-Hu-96Tests 96 Tests
EUR 724

Mouse V-Myc Myelocytomatosis Viral Oncogene Homolog (MYC) ELISA Kit

RDR-MYC-Mu-48Tests 48 Tests
EUR 534

Mouse V-Myc Myelocytomatosis Viral Oncogene Homolog (MYC) ELISA Kit

RDR-MYC-Mu-96Tests 96 Tests
EUR 742

Rat V-Myc Myelocytomatosis Viral Oncogene Homolog (MYC) ELISA Kit

RDR-MYC-Ra-48Tests 48 Tests
EUR 558

Rat V-Myc Myelocytomatosis Viral Oncogene Homolog (MYC) ELISA Kit

RDR-MYC-Ra-96Tests 96 Tests
EUR 776

Human V-Myc Myelocytomatosis Viral Oncogene Homolog (MYC) ELISA Kit

RD-MYC-Hu-48Tests 48 Tests
EUR 500

Human V-Myc Myelocytomatosis Viral Oncogene Homolog (MYC) ELISA Kit

RD-MYC-Hu-96Tests 96 Tests
EUR 692

Mouse V-Myc Myelocytomatosis Viral Oncogene Homolog (MYC) ELISA Kit

RD-MYC-Mu-48Tests 48 Tests
EUR 511

Mouse V-Myc Myelocytomatosis Viral Oncogene Homolog (MYC) ELISA Kit

RD-MYC-Mu-96Tests 96 Tests
EUR 709

Rat V-Myc Myelocytomatosis Viral Oncogene Homolog (MYC) ELISA Kit

RD-MYC-Ra-48Tests 48 Tests
EUR 534

Rat V-Myc Myelocytomatosis Viral Oncogene Homolog (MYC) ELISA Kit

RD-MYC-Ra-96Tests 96 Tests
EUR 742

c-Myc Epitope (Myc) Antibody

20-abx130438
  • EUR 314.00
  • EUR 759.00
  • EUR 411.00
  • EUR 154.00
  • EUR 244.00
  • 100 ug
  • 1 mg
  • 200 ug
  • 20 ug
  • 50 ug
  • Shipped within 5-7 working days.

c-Myc Epitope (Myc) Antibody

20-abx132269
  • EUR 439.00
  • EUR 133.00
  • EUR 1261.00
  • EUR 606.00
  • EUR 342.00
  • 100 ug
  • 10 ug
  • 1 mg
  • 200 ug
  • 50 ug
  • Shipped within 5-7 working days.

c-Myc Oncoprotein; Clone 9E10.3 (Concentrate)

RA0226-C.1 0.1 ml
EUR 125

c-Myc Oncoprotein; Clone 9E10.3 (Concentrate)

RA0226-C.5 0.5 ml
EUR 300

c-Myc Oncoprotein; Clone MYC909 (Concentrate)

RA0227-C.1 0.1 ml
EUR 125

c-Myc Oncoprotein; Clone MYC909 (Concentrate)

RA0227-C.5 0.5 ml
EUR 300

C-myc antibody

20R-CC001 200 ug
EUR 381
Description: Chicken polyclonal C-myc antibody

C-myc antibody

70R-10651 1 ml
EUR 430
Description: Affinity purified Chicken polyclonal C-myc antibody

C-myc antibody

70-CC18 100 ug
EUR 331
Description: Affinity purified Chicken polyclonal C-myc antibody

C-Myc Antibody

6767-100
EUR 316

C-myc Antibody

48044-100ul 100ul
EUR 333

C-myc Antibody

48044-50ul 50ul
EUR 239

c Myc antibody

10R-8403 100 ul
EUR 393
Description: Mouse monoclonal c Myc antibody

C-myc antibody

10R-C101a 100 ug
EUR 543
Description: Mouse monoclonal C-myc antibody

C-Myc Antibody

3995-100
EUR 327

C-Myc Antibody

3995-30T
EUR 146

C-myc antibody

70R-CG001 100 ul
EUR 381
Description: Affinity purified Goat polyclonal C-myc antibody

c-Myc antibody

70R-32862 100 ug
EUR 457
Description: Rabbit polyclonal c-Myc antibody

c-MYC Antibody

AF0358 200ul
EUR 304
Description: MYC antibody detects endogenous levels of total MYC.

Polyclonal MYC / c-Myc Antibody (aa25-74)

APR02915G 0.05ml
EUR 484
Description: A polyclonal antibody raised in Rabbit that recognizes and binds to Human MYC / c-Myc (aa25-74). This antibody is tested and proven to work in the following applications:

Polyclonal MYC / c-Myc Antibody (aa386-435)

APR02947G 0.05ml
EUR 484
Description: A polyclonal antibody raised in Rabbit that recognizes and binds to Human MYC / c-Myc (aa386-435). This antibody is tested and proven to work in the following applications:

Myc Proto-Oncogene Protein (c-Myc) Antibody

20-abx008959
  • EUR 300.00
  • EUR 439.00
  • EUR 189.00
  • 100 ul
  • 200 ul
  • 30 ul
  • Shipped within 5-10 working days.

Myc Proto-Oncogene Protein (c-Myc) Antibody

20-abx008960
  • EUR 300.00
  • EUR 439.00
  • EUR 189.00
  • 100 ul
  • 200 ul
  • 30 ul
  • Shipped within 5-10 working days.

Myc Proto-Oncogene Protein (c-Myc) Antibody

abx022462-02mg 0.2 mg
EUR 523
  • Shipped within 5-10 working days.

Myc Proto-Oncogene (c-Myc Peptide) Antibody

abx022463-02mg 0.2 mg
EUR 509
  • Shipped within 5-10 working days.

Myc Proto-Oncogene (C-Myc Peptide) Antibody

abx023934-100ug 100 ug
EUR 314
  • Shipped within 5-10 working days.

Myc Proto-Oncogene (C-Myc Peptide) Antibody

abx023935-01ml 0.1 ml
EUR 314
  • Shipped within 5-10 working days.

Myc Proto-Oncogene Protein (c-Myc) Antibody

abx018354-100ug 100 ug
EUR 495
  • Shipped within 5-10 working days.

Myc Proto-Oncogene Protein (c-Myc) Antibody

20-abx118000
  • EUR 551.00
  • EUR 481.00
  • 100 ul
  • 50 ul
  • Shipped within 5-10 working days.

Myc Proto-Oncogene Protein (c-Myc) Antibody

abx037911-100ug 100 ug
EUR 391
  • Shipped within 5-10 working days.

Myc Proto-Oncogene Protein (c-Myc) Antibody

20-abx133153
  • EUR 300.00
  • EUR 439.00
  • EUR 189.00
  • 100 ul
  • 200 ul
  • 30 ul
  • Shipped within 5-10 working days.

Myc Proto-Oncogene Protein (c-Myc) Antibody

20-abx133248
  • EUR 300.00
  • EUR 439.00
  • EUR 189.00
  • 100 ul
  • 200 ul
  • 30 ul
  • Shipped within 5-10 working days.

Myc Proto-Oncogene Protein (c-Myc) Antibody

20-abx133250
  • EUR 300.00
  • EUR 439.00
  • EUR 189.00
  • 100 ul
  • 200 ul
  • 30 ul
  • Shipped within 5-10 working days.

Myc Proto-Oncogene Protein (c-Myc) Antibody

20-abx133912
  • EUR 356.00
  • EUR 537.00
  • EUR 217.00
  • 100 ul
  • 200 ul
  • 30 ul
  • Shipped within 5-10 working days.

Myc Proto-Oncogene Protein (c-Myc) Antibody

20-abx137079
  • EUR 356.00
  • EUR 523.00
  • 0.5 mg
  • 1 mg
  • Shipped within 5-10 working days.

Myc Proto-Oncogene Protein (c-Myc) Antibody

abx139766-01mg 0.1 mg
EUR 384
  • Shipped within 5-12 working days.

Myc Proto-Oncogene Protein (c-Myc) Antibody

abx413504-01mg 0.1 mg
EUR 634
  • Shipped within 1 week.

Myc Proto-Oncogene Protein (c-Myc) Antibody

abx413821-1mg 1 mg
EUR 829
  • Shipped within 1 week.

Myc Proto-Oncogene Protein (c-Myc) Antibody

abx413825-2mg 2 mg
EUR 1525
  • Shipped within 1 week.

Myc Proto-Oncogene Protein (c-Myc) Antibody

abx413826-01mg 0.1 mg
EUR 411
  • Shipped within 1 week.

Myc Proto-Oncogene Protein (c-Myc) Antibody

abx413829-20ug 20 ug
EUR 272
  • Shipped within 1 week.

Myc Proto-Oncogene Protein (c-Myc) Antibody

abx448567-100ug 100 ug
EUR 523
  • Shipped within 5-12 working days.

Myc Proto-Oncogene Protein (c-Myc) Antibody

abx448568-100ug 100 ug
EUR 523
  • Shipped within 5-12 working days.

Myc Proto-Oncogene Protein (c-MYC) Antibody

abx231791-100ug 100 ug
EUR 551
  • Shipped within 5-12 working days.

Monoclonal MYC / c-Myc Antibody (aa408-420)

AMM02198G 0.05mg
EUR 484
Description: A Monoclonal antibody against Human MYC / c-Myc (aa408-420). The antibodies are raised in Mouse. This antibody is applicable in IHC-P, E

Human recombinant purified His-tag c-myc protein (~65 kda) control

MYC17-C 100 ul
EUR 286

C-Myc

MYCF-100T 100 test
EUR 505

c-Myc

RA25085 100 ul
EUR 513

C-myc HRP Antibody

48046-100ul 100ul
EUR 333

C-myc HRP Antibody

48046-50ul 50ul
EUR 239

c-Myc Tag Antibody

35536-100ul 100ul
EUR 252

C-myc antibody (FITC)

60R-1085 1 ml
EUR 397
Description: Affinity purified Chicken polyclonal C-myc antibody (FITC)

C-myc antibody (FITC)

60R-CG001FT 100 ug
EUR 489
Description: Goat polyclonal C-myc antibody (FITC) conjugated

C-myc antibody (HRP)

60R-CG001hrp 100 ug
EUR 478
Description: Goat polyclonal C-myc antibody (HRP) conjugated

c-Myc Polyclonal Antibody

40764-100ul 100ul
EUR 252

c-Myc Polyclonal Antibody

40764-50ul 50ul
EUR 187

c-Myc Polyclonal Antibody

40765-100ul 100ul
EUR 252

c-Myc Polyclonal Antibody

40765-50ul 50ul
EUR 187

c-Myc Polyclonal Antibody

40766-100ul 100ul
EUR 252

c-Myc Polyclonal Antibody

40766-50ul 50ul
EUR 187

Polyclonal C-Myc Antibody

APR00240G 0.1mg
EUR 484
Description: A polyclonal antibody raised in Rabbit that recognizes and binds to Human C-Myc . This antibody is tested and proven to work in the following applications:

c-Myc (pT58) Antibody

20-abx009775
  • EUR 314.00
  • EUR 467.00
  • EUR 203.00
  • 100 ul
  • 200 ul
  • 30 ul
  • Shipped within 5-10 working days.

c-Myc (pS62) Antibody

20-abx009776
  • EUR 314.00
  • EUR 467.00
  • EUR 203.00
  • 100 ul
  • 200 ul
  • 30 ul
  • Shipped within 5-10 working days.

c-Myc Polyclonal Antibody

ABP55308-003ml 0.03ml
EUR 158
  • Immunogen information: Synthesized peptide derived from human c-Myc around the non-phosphorylation site of T58
  • Applications tips:
Description: A polyclonal antibody for detection of c-Myc from Human, Mouse, Rat. This c-Myc antibody is for WB, IHC-P, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from human c-Myc around the non-phosphorylation site of T58

c-Myc Polyclonal Antibody

ABP55308-01ml 0.1ml
EUR 289
  • Immunogen information: Synthesized peptide derived from human c-Myc around the non-phosphorylation site of T58
  • Applications tips:
Description: A polyclonal antibody for detection of c-Myc from Human, Mouse, Rat. This c-Myc antibody is for WB, IHC-P, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from human c-Myc around the non-phosphorylation site of T58

c-Myc Polyclonal Antibody

ABP55308-02ml 0.2ml
EUR 414
  • Immunogen information: Synthesized peptide derived from human c-Myc around the non-phosphorylation site of T58
  • Applications tips:
Description: A polyclonal antibody for detection of c-Myc from Human, Mouse, Rat. This c-Myc antibody is for WB, IHC-P, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from human c-Myc around the non-phosphorylation site of T58

c-Myc Polyclonal Antibody

ABP55309-003ml 0.03ml
EUR 158
  • Immunogen information: Synthesized peptide derived from human c-Myc around the non-phosphorylation site of S373
  • Applications tips:
Description: A polyclonal antibody for detection of c-Myc from Human, Mouse, Rat. This c-Myc antibody is for WB, IHC-P, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from human c-Myc around the non-phosphorylation site of S373

c-Myc Polyclonal Antibody

ABP55309-01ml 0.1ml
EUR 289
  • Immunogen information: Synthesized peptide derived from human c-Myc around the non-phosphorylation site of S373
  • Applications tips:
Description: A polyclonal antibody for detection of c-Myc from Human, Mouse, Rat. This c-Myc antibody is for WB, IHC-P, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from human c-Myc around the non-phosphorylation site of S373

c-Myc Polyclonal Antibody

ABP55309-02ml 0.2ml
EUR 414
  • Immunogen information: Synthesized peptide derived from human c-Myc around the non-phosphorylation site of S373
  • Applications tips:
Description: A polyclonal antibody for detection of c-Myc from Human, Mouse, Rat. This c-Myc antibody is for WB, IHC-P, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from human c-Myc around the non-phosphorylation site of S373

C-Myc Antibody (FITC)

abx201112-100tests 100 tests
EUR 592
  • Shipped within 2-3 weeks.

c-Myc (pT358) Antibody

20-abx133249
  • EUR 314.00
  • EUR 467.00
  • EUR 203.00
  • 100 ul
  • 200 ul
  • 30 ul
  • Shipped within 5-10 working days.

c-Myc Antibody (HRP)

abx139767-01mg 0.1 mg
EUR 578
  • Shipped within 5-12 working days.

c-Myc Antibody (Biotin)

abx139768-01mg 0.1 mg
EUR 481
  • Shipped within 5-12 working days.

c-Myc Antibody (FITC)

abx139769-01mg 0.1 mg
EUR 481
  • Shipped within 5-12 working days.

c-Myc Polyclonal Antibody

EA053-100ul 100ul
EUR 279
Description: A Rabbit Polyclonal antibody against c-Myc from Human. This antibody is tested and validated for WB, ELISA, IHC

c-Myc Polyclonal Antibody

EA053-50ul 50ul
EUR 207
Description: A Rabbit Polyclonal antibody against c-Myc from Human. This antibody is tested and validated for WB, ELISA, IHC

C-myc Conjugated Antibody

C48044 100ul
EUR 397

c-Myc(MYC909) Antibody

BNUM0909-50 50uL
EUR 395
Description: Primary antibody against c-Myc(MYC909), 1mg/mL

c-Myc(MYC275) Antibody

BNUB0275-100 100uL
EUR 209
Description: Primary antibody against c-Myc(MYC275), Concentration: 0.2mg/mL

c-Myc(MYC275) Antibody

BNUB0275-500 500uL
EUR 458
Description: Primary antibody against c-Myc(MYC275), Concentration: 0.2mg/mL

c-Myc(9E10.) Antibody

BNUB0596-100 100uL
EUR 209
Description: Primary antibody against c-Myc(9E10.), Concentration: 0.2mg/mL

c-Myc(9E10.) Antibody

BNUB0596-500 500uL
EUR 458
Description: Primary antibody against c-Myc(9E10.), Concentration: 0.2mg/mL

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